Open AccessAncestry matters: Building inclusivity into preclinical study design
Author(s) -
Sophie Zaaijer,
Amanda CapesDavis
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.03.041
Subject(s) - biology , biomedicine , diversity (politics) , cls upper limits , computational biology , key (lock) , engineering ethics , genetics , ecology , anthropology , sociology , medicine , optometry , engineering
Human cell lines (CLs) are key assets for biomedicine but lack ancestral diversity. Here, we explore why genetic diversity among cell-based models is essential for making preclinical research more equitable and widely translatable. We lay out practical actions that can be taken to improve inclusivity in study design.
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