Open AccessNeu(ronal) custodians of cutaneous immunity
Author(s) -
Kody Mansfield,
Shruti Naik
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.03.040
Subject(s) - biology , inflammation , neuroscience , immunology , secretion , immunity , immune system , microbiology and biotechnology , homeostasis , mast cell , cell , genetics , biochemistry
Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD + nonpeptidergic neurons that restrain MC activation via glutamate secretion.
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