Decaf or regular? Energizing the caffeine receptor | Zendy

Edward L. Stahl | Zendy; Laura Bohn | Zendy

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Decaf or regular? Energizing the caffeine receptor

Author(s) -

Edward L. Stahl,

Laura Bohn

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.03.016

Subject(s) - partial agonist , g protein coupled receptor , biology , adenosine receptor , agonist , pharmacology , receptor , adenylyl cyclase , adenosine , terbutaline , stimulation , medicine , endocrinology , immunology , biochemistry , asthma

Partial agonism describes the relative efficacy of a drug compared to one that produces a greater response in a particular system; the designation is dependent upon the comparator and the system. In this issue of Cell, Huang et al. describe biophysical approaches to define the signature of GPCR partial agonists, providing direct measures of varying intrinsic efficacy.

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