An expanded universe of cancer targets | Zendy

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An expanded universe of cancer targets

Author(s) -

William C. Hahn,

Joel S. Bader,

Theodore P. Braun,

Andrea Califano,

Paul A. Clemons,

Brian J. Druker,

Andrew J. Ewald,

Haian Fu,

Subhashini Jagu,

Christopher J. Kemp,

William Kim,

Calvin J. Kuo,

Michael T. McManus,

Gordon B. Mills,

Xiulei Mo,

Nidhi Sahni,

Stuart L. Schreiber,

Jessica A. Talamas,

Pablo Tamayo,

Jeffrey W. Tyner,

Bridget K. Wagner,

William A. Weiss,

Daniela S. Gerhard,

Vlado Dančík,

Shubhroz Gill,

Bruce K. Hua,

Tanaz Sharifnia,

Vasanthi S. Viswanathan,

Yilong Zou,

Filemon S. Dela Cruz,

Andrew L. Kung,

Brent R. Stockwell,

Jesse S. Boehm,

Josh Dempster,

Robert T. Manguso,

Francisca Vázquez,

Lee Cooper,

Yuhong Du,

Andrei A. Ivanov,

Sagar Lonial,

Carlos S. Moreno,

Qiankun Niu,

Taofeek K. Owonikoko,

Suresh S. Ramalingam,

Matthew A. Reyna,

Wei Zhou,

Carla Grandori,

Ilya Shmulevich,

Elizabeth M. Swisher,

Jitong Cai,

Isaac S. Chan,

Matthew Dunworth,

Yuchen Ge,

Dan Georgess,

Eloïse M. Grasset,

Elodie Henriet,

Hildur Knútsdóttir,

Michael G. Lerner,

Veena Padmanaban,

Matthew C. Perrone,

Yasir Suhail,

Yohannes Tsehay,

Manisha Warrier,

Quin Morrow,

Tamilla Nechiporuk,

Nicola Long,

Jennifer N. Saultz,

Andy Kaempf,

Jessica Minnier,

Cristina E. Tog,

Stephen E. Kurtz,

Anupriya Agarwal,

Jordana F. Brown,

Kevin WatanabeSmith,

Tania Q. Vu,

Thomas Jacob,

Yunqi Yan,

Bridget A. Robinson,

Evan Lind,

Yoko Kosaka,

Emek Demir,

Joseph Estabrook,

Michael Grzadkowski,

Olga Nikolova,

Ken Chen,

Ben Deneen,

Han Liang,

Michael C. Bassik,

Asmita Bhattacharya,

Kevin Brennan,

Christina Curtis,

Olivier Gevaert,

Hanlee P. Ji,

Kasper Karlsson,

Kremena Karagyozova,

YuanHung Lo,

Katherine Liu,

Michitaka Nakano,

Anuja Sathe,

Amber R. Smith,

Kaitlyn Spees,

Winghing Wong,

Kanako Yuki,

Matt Hangauer,

Dan S. Kaufman,

Allan Balmain,

Saumya Bollam,

Wei-Ching Chen,

Qi-Wen Fan,

Kelly Kersten,

Matthew F. Krummel,

Leslie A. Lange,

Marie Ménard,

Nicole Nasholm,

Christin Schmidt,

Nina K. Serwas,

Hiroyuki Yoda,

Alan Ashworth,

Sourav Bandyopadhyay,

Trevor Bivona,

Gabriel Eades,

Stefan Oberlin,

Neil Q. Tay,

Yuhao Wang,

Jonathan S. Weissman

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.02.020

Subject(s) - biology , oncogene , genome , cancer , computational biology , function (biology) , gene , translation (biology) , genetics , cancer therapy , cancer cell , genomics , messenger rna , cell cycle

The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation.

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