Open AccessA vicious cycle in atherosclerosis
Author(s) -
Aldons J. Lusis
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.02.005
Subject(s) - leukocytosis , myocardial infarction , biology , somatic cell , haematopoiesis , immunology , stem cell , coronary artery disease , blood cell , disease , medicine , genetics , gene
Clonal hematopoiesis, defined as the presence of expanded somatic blood cell clones, is associated with about a doubling in the risk of coronary heart disease in humans. Heyde and colleagues now provide evidence that clonal hematopoiesis results largely from increased stem cell proliferation, which is, in turn, stimulated by atherosclerosis.
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