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Bones of contention: skeletal patterning across the fin-to-limb transition
Author(s) -
Frank J. Tulenko,
Peter D. Currie
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.01.039
Subject(s) - biology , hox gene , vertebrate , evolutionary developmental biology , anatomy , evolutionary biology , limb development , developmental genetics , fin , pectoral girdle , microbiology and biotechnology , regulation of gene expression , genetics , materials science , gene , composite material , embryo , transcription factor
The fin-to-limb transition has long fascinated evolutionary biologists, but a unifying theory as to its developmental origins has remained elusive. New work by Hawkins and colleagues demonstrates the surprising potential of teleost fins to exhibit a Hox-regulated limb-like skeletal pattern, shedding new light on the evolution of proximo-distal patterning processes.

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