Training the metaorganism: the microbial counterpart | Zendy

Irah L. King | Zendy; Maziar Divangahi | Zendy

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Training the metaorganism: the microbial counterpart

Author(s) -

Irah L. King,

Maziar Divangahi

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.01.009

Subject(s) - biology , innate immune system , heterologous , immunity , immunology , immune system , immunization , immunological memory , colonisation resistance , resistance (ecology) , colonization , microbiology and biotechnology , genetics , ecology , gene

Infection or immunization can reprogram innate immune cells generating memory responses with broad protection against subsequent infection, a process referred to as "trained immunity." A new study by Stacy and colleagues demonstrates that, following acute infection, the commensal microbiota can also be "trained" to enhance colonization resistance against heterologous infection.

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