Breathing new life into the rational design of Alzheimer’s therapeutics | Zendy

Daniel R. Dries | Zendy; Gang Yu | Zendy

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Breathing new life into the rational design of Alzheimer’s therapeutics

Author(s) -

Daniel R. Dries,

Gang Yu

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.12.036

Subject(s) - disease , amyloid precursor protein secretase , biology , drug discovery , neuroscience , drug development , mechanism (biology) , gamma secretase , alzheimer's disease , bioinformatics , pharmacology , computational biology , drug , amyloid precursor protein , medicine , microbiology and biotechnology , pathology , philosophy , epistemology

γ-secretase is a promising therapeutic target for Alzheimer's disease, but all inhibitors and modulators have failed due to toxicity or low efficacy. In this issue of Cell, Yang et al. provide cryo-EM structures of γ-secretase bound to three inhibitors and a modulator, giving new promise to targeting γ-secretase therapeutically.

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