A MicroRNA Linking Human Positive Selection and Metabolic Disorders | Zendy

Lifeng Wang | Zendy; Nasa Sinnott-Armstrong | Zendy; Alexandre Wagschal | Zendy; Abigail R. Wark | Zendy; João Paulo Camporez | Zendy; Rachel J. Perry | Zendy; Fei Ji | Zendy; Yoojin Sohn | Zendy; Justin D. Oh | Zendy; Su Wu | Zendy; Jessica Chery | Zendy; Bahareh Nemati Moud | Zendy; Alham Saadat | Zendy; Simon N. Dankel | Zendy; Gunnar Mellgren | Zendy; Divya Sri Priyanka Tallapragada | Zendy; Sophie Strobel | Zendy; MiJeong Lee | Zendy; Ryan Tewhey | Zendy; Pardis C. Sabeti | Zendy; Anne Schaefer | Zendy; Andreas Petri | Zendy; Sakari Kauppinen | Zendy; Raymond T. Chung | Zendy; Alexander A. Soukas | Zendy; Joseph Avruch | Zendy; Susan K. Fried | Zendy; Hans Hauner | Zendy; Ruslan I. Sadreyev | Zendy; Gerald I. Shulman | Zendy; Melina Claussnitzer | Zendy; Anders M. Näär | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A MicroRNA Linking Human Positive Selection and Metabolic Disorders

Author(s) -

Lifeng Wang,

Nasa Sinnott-Armstrong,

Alexandre Wagschal,

Abigail R. Wark,

João Paulo Camporez,

Rachel J. Perry,

Fei Ji,

Yoojin Sohn,

Justin D. Oh,

Su Wu,

Jessica Chery,

Bahareh Nemati Moud,

Alham Saadat,

Simon N. Dankel,

Gunnar Mellgren,

Divya Sri Priyanka Tallapragada,

Sophie Strobel,

MiJeong Lee,

Ryan Tewhey,

Pardis C. Sabeti,

Anne Schaefer,

Andreas Petri,

Sakari Kauppinen,

Raymond T. Chung,

Alexander A. Soukas,

Joseph Avruch,

Susan K. Fried,

Hans Hauner,

Ruslan I. Sadreyev,

Gerald I. Shulman,

Melina Claussnitzer,

Anders M. Näär

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.09.017

Subject(s) - biology , maladaptation , locus (genetics) , genetics , phenotype , natural selection , gene , obesity , selection (genetic algorithm) , endocrinology , artificial intelligence , computer science

Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also associated with obesity and type 2 diabetes in humans, raising the possibility that additional genetic elements in the locus may have contributed to evolutionary adaptation to famine by promoting energy storage, but which now confer susceptibility to metabolic diseases. We show here that the miR-128-1 microRNA, located at the center of the positively selected locus, represents a crucial metabolic regulator in mammals. Antisense targeting and genetic ablation of miR-128-1 in mouse metabolic disease models result in increased energy expenditure and amelioration of high-fat-diet-induced obesity and markedly improved glucose tolerance. A thrifty phenotype connected to miR-128-1-dependent energy storage may link ancient adaptation to famine and modern metabolic maladaptation associated with nutritional overabundance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research