cAMP Signaling in Nanodomains | Zendy

Peter K. Jackson | Zendy

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cAMP Signaling in Nanodomains

Author(s) -

Peter K. Jackson

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.08.041

Subject(s) - cyclic adenosine monophosphate , biology , second messenger system , phosphodiesterase , protein kinase a , signal transduction , microbiology and biotechnology , adenosine , cell signaling , scaffold protein , adenylate kinase , kinase , biochemistry , enzyme , receptor

Cyclic-3',5'-adenosine monophosphate (cAMP) is an ancient second messenger but organizing signaling selectivity on the nanoscale is poorly understood. Examining transport of a new fluorescent cAMP probe, Bock and coworkers observe "buffered diffusion" and establish phosphodiesterase activity can organize cAMP nanodomains, while Zhao and coworkers find that protein kinase A regulatory subunits assemble liquid droplets to further localize cAMP signaling.

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