A Metabolic Bottleneck for Stem Cell Transformation | Zendy

Sanjeethan C. Baksh | Zendy; Elaine Fuchs | Zendy

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A Metabolic Bottleneck for Stem Cell Transformation

Author(s) -

Sanjeethan C. Baksh,

Elaine Fuchs

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.08.038

Subject(s) - stem cell , biology , cancer stem cell , reprogramming , stem cell theory of aging , cancer research , microbiology and biotechnology , cd44 , stem cell marker , carcinogenesis , tumor initiation , adult stem cell , cellular differentiation , progenitor cell , cell , cancer , genetics , stem cell factor , gene

Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization remain unknown. In this issue of Cell, Bonnay et al. identify enhanced electron transport chain activity as a critical determinant of this process, establishing metabolic reprogramming as limiting for tumor initiation.

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