Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment | Zendy

Jonas Schulte-Schrepping | Zendy; Nico Reusch | Zendy; Daniela Paclik | Zendy; Kevin Baßler | Zendy; Stephan Schlickeiser | Zendy; Bowen Zhang | Zendy; Benjamin Krämer | Zendy; Tobias Krammer | Zendy; Sophia Brumhard | Zendy; Lorenzo Bonaguro | Zendy; Elena De Domenico | Zendy; Daniel Wendisch | Zendy; Martin Graßhoff | Zendy; Theodore S. Kapellos | Zendy; Michael Beckstette | Zendy; Tal Pecht | Zendy; Adem Saglam | Zendy; Oliver Dietrich | Zendy; Henrik E. Mei | Zendy; Axel Schulz | Zendy; Claudia Conrad | Zendy; Désirée Kunkel | Zendy; Ehsan Vafadarnejad | Zendy; ChengJian Xu | Zendy; Arik Horne | Zendy; Miriam Herbert | Zendy; Anna Drews | Zendy; Charlotte Thibeault | Zendy; Moritz Pfeiffer | Zendy; Stefan Hippenstiel | Zendy; Andreas C. Hocke | Zendy; Holger Müller-Redetzky | Zendy; Kathrin Heim | Zendy; Felix Machleidt | Zendy; Alexander Uhrig | Zendy; Laure Bosquillon de Jarcy | Zendy; Linda Jürgens | Zendy; Miriam Stegemann | Zendy; Christoph R. Glösenkamp | Zendy; HansDieter Volk | Zendy; Christine Goffinet | Zendy; Markus Landthaler | Zendy; Emanuel Wyler | Zendy; Philipp Georg | Zendy; Maria Schneider | Zendy; Chantip DangHeine | Zendy; Nick Neuwinger | Zendy; Kai Kappert | Zendy; R Tauber | Zendy; Victor M. Corman | Zendy; Jan Raabe | Zendy; Kim M Kaiser | Zendy; M To Vinh | Zendy; Gereon Rieke | Zendy; Christian Meisel | Zendy; Thomas Ulas | Zendy; Matthias Becker | Zendy; Robert Geffers | Zendy; Martin Witzenrath | Zendy; Christian Drosten | Zendy; Norbert Suttorp | Zendy; Christof von Kalle | Zendy; Florian Kurth | Zendy; Kristian Händler | Zendy; Joachim L. Schultze | Zendy; Anna C. Aschenbrenner | Zendy; Yang Li | Zendy; Jacob Nattermann | Zendy; Birgit Sawitzki | Zendy; AntoineEmmanuel Saliba | Zendy; Leif Erik Sander | Zendy; Angel Angelov | Zendy; Robert Bals | Zendy; Alexander Bartholomäus | Zendy; Anke Becker | Zendy; Daniela Bezdan | Zendy; Ezio Bonifacio | Zendy; Peer Bork | Zendy; Thomas Clavel | Zendy; Maria ColoméTatché | Zendy; Andreas Diefenbach | Zendy; Alexander Dilthey | Zendy; Nicole Fischer | Zendy; Konrad U. Förstner | Zendy; Julia-Stefanie Frick | Zendy; Julien Gagneur | Zendy; Alexander Goesmann | Zendy; Torsten Hain | Zendy; Michael Hummel | Zendy; Stefan Janssen | Zendy; Jörn Kalinowski | Zendy; René Kallies | Zendy; Birte Kehr | Zendy; Andreas Keller | Zendy; Sarah Kim-Hellmuth | Zendy; Christoph Klein | Zendy; Oliver Kohlbacher | Zendy; Jan O. Korbel | Zendy; Ingo Kurth | Zendy; Kerstin U. Ludwig | Zendy; Oliwia Makarewicz | Zendy; Manja Marz | Zendy; Alice C. McHardy | Zendy; Christian Mertes | Zendy; Markus M. Nöthen | Zendy; Peter Nürnberg | Zendy; Uwe Ohler | Zendy; Stephan Ossowski | Zendy; Jörg Overmann | Zendy; Silke Peter | Zendy; Klaus Pfeffer | Zendy; Anna R. Poetsch | Zendy; Alfred Pühler | Zendy; Nikolaus Rajewsky | Zendy; Markus Ralser | Zendy; Olaf Rieß | Zendy; Stephan Ripke | Zendy; Ulisses Nunes da Rocha | Zendy; Philip Rosenstiel | Zendy; Philipp H. Schiffer | Zendy; Eva C. Schulte | Zendy; Alexander Sczyrba | Zendy; Oliver Stegle | Zendy; Jens Stoye | Zendy; Fabian J. Theis | Zendy; Jörg Janne Vehreschild | Zendy; Jörg Vogel | Zendy; Max von Kleist | Zendy; Andreas Walker | Zendy; Jörn Walter | Zendy; Dagmar Wieczorek | Zendy; John Ziebuhr | Zendy

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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Author(s) -

Jonas Schulte-Schrepping,

Nico Reusch,

Daniela Paclik,

Kevin Baßler,

Stephan Schlickeiser,

Bowen Zhang,

Benjamin Krämer,

Tobias Krammer,

Sophia Brumhard,

Lorenzo Bonaguro,

Elena De Domenico,

Daniel Wendisch,

Martin Graßhoff,

Theodore S. Kapellos,

Michael Beckstette,

Tal Pecht,

Adem Saglam,

Oliver Dietrich,

Henrik E. Mei,

Axel Schulz,

Claudia Conrad,

Désirée Kunkel,

Ehsan Vafadarnejad,

ChengJian Xu,

Arik Horne,

Miriam Herbert,

Anna Drews,

Charlotte Thibeault,

Moritz Pfeiffer,

Stefan Hippenstiel,

Andreas C. Hocke,

Holger Müller-Redetzky,

Kathrin Heim,

Felix Machleidt,

Alexander Uhrig,

Laure Bosquillon de Jarcy,

Linda Jürgens,

Miriam Stegemann,

Christoph R. Glösenkamp,

HansDieter Volk,

Christine Goffinet,

Markus Landthaler,

Emanuel Wyler,

Philipp Georg,

Maria Schneider,

Chantip DangHeine,

Nick Neuwinger,

Kai Kappert,

R Tauber,

Victor M. Corman,

Jan Raabe,

Kim M Kaiser,

M To Vinh,

Gereon Rieke,

Christian Meisel,

Thomas Ulas,

Matthias Becker,

Robert Geffers,

Martin Witzenrath,

Christian Drosten,

Norbert Suttorp,

Christof von Kalle,

Florian Kurth,

Kristian Händler,

Joachim L. Schultze,

Anna C. Aschenbrenner,

Yang Li,

Jacob Nattermann,

Birgit Sawitzki,

AntoineEmmanuel Saliba,

Leif Erik Sander,

Angel Angelov,

Robert Bals,

Alexander Bartholomäus,

Anke Becker,

Daniela Bezdan,

Ezio Bonifacio,

Peer Bork,

Thomas Clavel,

Maria ColoméTatché,

Andreas Diefenbach,

Alexander Dilthey,

Nicole Fischer,

Konrad U. Förstner,

Julia-Stefanie Frick,

Julien Gagneur,

Alexander Goesmann,

Torsten Hain,

Michael Hummel,

Stefan Janssen,

Jörn Kalinowski,

René Kallies,

Birte Kehr,

Andreas Keller,

Sarah Kim-Hellmuth,

Christoph Klein,

Oliver Kohlbacher,

Jan O. Korbel,

Ingo Kurth,

Kerstin U. Ludwig,

Oliwia Makarewicz,

Manja Marz,

Alice C. McHardy,

Christian Mertes,

Markus M. Nöthen,

Peter Nürnberg,

Uwe Ohler,

Stephan Ossowski,

Jörg Overmann,

Silke Peter,

Klaus Pfeffer,

Anna R. Poetsch,

Alfred Pühler,

Nikolaus Rajewsky,

Markus Ralser,

Olaf Rieß,

Stephan Ripke,

Ulisses Nunes da Rocha,

Philip Rosenstiel,

Philipp H. Schiffer,

Eva C. Schulte,

Alexander Sczyrba,

Oliver Stegle,

Jens Stoye,

Fabian J. Theis,

Jörg Janne Vehreschild,

Jörg Vogel,

Max von Kleist,

Andreas Walker,

Jörn Walter,

Dagmar Wieczorek,

John Ziebuhr

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.08.001

Subject(s) - biology , covid-19 , compartment (ship) , myeloid , myeloid cells , pandemic , virology , cell , immunology , genetics , outbreak , medicine , disease , infectious disease (medical specialty) , oceanography , geology

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DR hi CD11c hi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DR lo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

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