Open AccessMyeloid Cells TREM Down Anti-tumor Responses
Author(s) -
Aimée Bugler-Lamb,
Martin Guilliams
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.07.042
Subject(s) - trem2 , biology , immune system , apolipoprotein e , cancer research , microglia , myeloid , immune checkpoint , disease , cancer , immunology , immunotherapy , myeloid cells , medicine , inflammation , genetics
In this issue of Cell, Molgora et al. and Katzenelenbogen, Sheban, Yalin, et al. highlight the novel role of TREM2 in shaping the immunosuppressive profile of tumor-associated myeloid cells and report that complementing immune-checkpoint therapy with TREM2 blockade induces stronger anti-tumor immune responses and reduces tumor growth.
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