Open AccessFinding a Needle in a Haystack: Identification of a Beige Fat Progenitor
Author(s) -
Claudio J. Villanueva
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.07.014
Subject(s) - adipose tissue , biology , adipocyte , progenitor cell , microbiology and biotechnology , thermogenesis , white adipose tissue , cell type , adipose tissue macrophages , cell , medicine , endocrinology , stem cell , biochemistry
Oguri and colleagues use single-cell RNA sequencing to identify a beige adipocyte precursor cell that gives rise to thermogenic adipocytes in subcutaneous adipose tissue. These beige fat progenitors are marked by PDGFRα, Sca1, and CD81 and proliferate upon activation of FAK-signaling in response to the cold and irisin.
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