Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear | Zendy

Nathan D. Grubaugh | Zendy; William P. Hanage | Zendy; Angela L. Rasmussen | Zendy

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Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear

Author(s) -

Nathan D. Grubaugh,

William P. Hanage,

Angela L. Rasmussen

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.06.040

Subject(s) - biology , pandemic , covid-19 , mutation , virology , sense (electronics) , genetics , gene , disease , outbreak , infectious disease (medical specialty) , medicine , electrical engineering , engineering

In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown.

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