Open AccessBreast Milk Modulates Transgenerational Immune Inheritance
Author(s) -
Jakob Zimmermann,
Andrew J. Macpherson
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.05.030
Subject(s) - biology , transgenerational epigenetics , inheritance (genetic algorithm) , immune system , genetics , breast milk , gene , pregnancy , offspring , biochemistry
ROR-γ + regulatory T cells (Tregs) of the colon can prevent excessive inflammation but also delay pathogen clearance. How these cells are regulated has remained elusive. In this issue of Cell, Ramanan et al. find that the set-point for ROR-γ + Tregs is non-genetically maternally inherited during a critical time window after birth through immunoglobulin A present in breast milk.
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