A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection | Zendy

JeanLaurent Casanova | Zendy; Helen C. Su | Zendy; Laurent Abel | Zendy; Alessandro Aiuti | Zendy; Saleh AlMuhsen | Zendy; Andrés A. Arias | Zendy; Paul Bastard | Zendy; Catherine M. Biggs | Zendy; Dusan Bogunovic | Zendy; Bertrand Boisson | Zendy; Stéphanie BoissonDupuis | Zendy; Alexandre Bolze | Zendy; Анастасія Бондаренко | Zendy; Aziz Bousfiha | Zendy; Petter Brodin | Zendy; Jacinta Bustamante | Zendy; Manish J. Butte | Zendy; Giorgio Casari | Zendy; Michael J. Ciancanelli | Zendy; Aurélie Cobat | Zendy; Antônio CondinoNeto | Zendy; Megan A. Cooper | Zendy; Clifton L. Dalgard | Zendy; Sara Espinosa | Zendy; Hagit Baris Feldman | Zendy; Jacques Fellay | Zendy; José Luis Franco | Zendy; David Hagin | Zendy; Yuval Itan | Zendy; Emmanuelle Jouanguy | Zendy; C. Lucas | Zendy; Davood Mansouri | Zendy; Isabelle Meyts | Zendy; Joshua D. Milner | Zendy; Trine H. Mogensen | Zendy; Tomohiro Morio | Zendy; Lisa F. P. Ng | Zendy; Luigi D. Notarangelo | Zendy; Satoshi Okada | Zendy; Tayfun Özçelık | Zendy; Pere SolerPalacín | Zendy; Anna M. Planas | Zendy; Carolina Prando | Zendy; Anne Puel | Zendy; Aurora Pujol | Zendy; Claire Redin | Zendy; Laurent Rénia | Zendy; Carlos RodríguezGallego | Zendy; Lluís QuintanaMurci | Zendy; Vanessa SanchoShimizu | Zendy; Vijay G. Sankaran | Zendy; Mikko Seppänen | Zendy; Mohammad Shahrooei | Zendy; Andrew L. Snow | Zendy; András N. Spaan | Zendy; Stuart G. Tangye | Zendy; Jordi PèrezTur | Zendy; Stuart E. Turvey | Zendy; Donald C. Vinh | Zendy; Horst von Bernuth | Zendy; Xiaochuan Wang | Zendy; Paweł Zawadzki | Zendy; Qian Zhang | Zendy; ShenYing Zhang | Zendy

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A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Author(s) -

JeanLaurent Casanova,

Helen C. Su,

Laurent Abel,

Alessandro Aiuti,

Saleh AlMuhsen,

Andrés A. Arias,

Paul Bastard,

Catherine M. Biggs,

Dusan Bogunovic,

Bertrand Boisson,

Stéphanie BoissonDupuis,

Alexandre Bolze,

Анастасія Бондаренко,

Aziz Bousfiha,

Petter Brodin,

Jacinta Bustamante,

Manish J. Butte,

Giorgio Casari,

Michael J. Ciancanelli,

Aurélie Cobat,

Antônio CondinoNeto,

Megan A. Cooper,

Clifton L. Dalgard,

Sara Espinosa,

Hagit Baris Feldman,

Jacques Fellay,

José Luis Franco,

David Hagin,

Yuval Itan,

Emmanuelle Jouanguy,

C. Lucas,

Davood Mansouri,

Isabelle Meyts,

Joshua D. Milner,

Trine H. Mogensen,

Tomohiro Morio,

Lisa F. P. Ng,

Luigi D. Notarangelo,

Satoshi Okada,

Tayfun Özçelık,

Pere SolerPalacín,

Anna M. Planas,

Carolina Prando,

Anne Puel,

Aurora Pujol,

Claire Redin,

Laurent Rénia,

Carlos RodríguezGallego,

Lluís QuintanaMurci,

Vanessa SanchoShimizu,

Vijay G. Sankaran,

Mikko Seppänen,

Mohammad Shahrooei,

Andrew L. Snow,

András N. Spaan,

Stuart G. Tangye,

Jordi PèrezTur,

Stuart E. Turvey,

Donald C. Vinh,

Horst von Bernuth,

Xiaochuan Wang,

Paweł Zawadzki,

Qian Zhang,

ShenYing Zhang

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.05.016

Subject(s) - biology , immunity , covid-19 , virology , genetics , immune system , infectious disease (medical specialty) , disease , outbreak , medicine , pathology

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.

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