Biasing Neurotensin Receptor Signaling to Arrest Psychostimulant Abuse | Zendy

Lauren K. Dobbs | Zendy; Hitoshi Morikawa | Zendy

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Biasing Neurotensin Receptor Signaling to Arrest Psychostimulant Abuse

Author(s) -

Lauren K. Dobbs,

Hitoshi Morikawa

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.05.009

Subject(s) - g protein coupled receptor , signal transduction , biology , g protein , microbiology and biotechnology , receptor , neurotensin receptor , arrestin , functional selectivity , heterotrimeric g protein , internalization , neurotensin , biochemistry , neuropeptide

Biasing G protein-coupled receptor signaling with ligands that promote select pathways is emerging as a powerful approach for therapeutic drug discovery. In this issue of Cell, Slosky et al. report a β-arrestin-biased neurotensin receptor ligand that may curtail drug abuse without the side effects induced by G protein signaling.

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