SnapShot: Jak-STAT Signaling II | Zendy

Alejandro V. Villarino | Zendy; Massimo Gadina | Zendy; John J. O’Shea | Zendy; Yuka Kanno | Zendy

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SnapShot: Jak-STAT Signaling II

Author(s) -

Alejandro V. Villarino,

Massimo Gadina,

John J. O’Shea,

Yuka Kanno

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.04.052

Subject(s) - biology , snapshot (computer storage) , stat , jak stat signaling pathway , signal transduction , microbiology and biotechnology , genetics , stat3 , receptor tyrosine kinase , computer science , operating system

The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or Jakinibs).

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