Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma | Zendy

Kulandaimanuvel Antony Michealraj | Zendy; Sachin Kumar | Zendy; Leo J.Y. Kim | Zendy; Florence M.G. Cavalli | Zendy; David Przelicki | Zendy; John Wojcik | Zendy; Alberto Delaidelli | Zendy; Andrea Bajic | Zendy; Olivier Saulnier | Zendy; Graham MacLeod | Zendy; Ravi N. Vellanki | Zendy; Maria C. Vladoiu | Zendy; Paul Guilhamon | Zendy; Winnie Ong | Zendy; John J. Y. Lee | Zendy; Yanqing Jiang | Zendy; Borja Holgado | Zendy; Alex Rasnitsyn | Zendy; Ahmad Malik | Zendy; Ricky Tsai | Zendy; Cory Richman | Zendy; Kyle Juraschka | Zendy; Joonas Haapasalo | Zendy; Evan Y. Wang | Zendy; Pasqualino de Antonellis | Zendy; Hiromichi Suzuki | Zendy; Hamza Farooq | Zendy; Polina Balin | Zendy; Kaitlin Kharas | Zendy; Randy Van Ommeren | Zendy; Olga Sirbu | Zendy; Avesta Rastan | Zendy; Stacey Krumholtz | Zendy; Michelle Ly | Zendy; Moloud Ahmadi | Zendy; Geneviève Deblois | Zendy; Dilakshan Srikanthan | Zendy; Betty Luu | Zendy; James Loukides | Zendy; Xiaochong Wu | Zendy; Livia Garzia | Zendy; Vijay Ramaswamy | Zendy; Evgeny Kanshin | Zendy; María SánchezOsuna | Zendy; Ibrahim El-Hamamy | Zendy; Fiona J. Coutinho | Zendy; Panagiotis Prinos | Zendy; Sheila K. Singh | Zendy; Laura Donovan | Zendy; Craig Daniels | Zendy; Daniel Schramek | Zendy; Mike Tyers | Zendy; Samuel Weiss | Zendy; Lincoln Stein | Zendy; Mathieu Lupien | Zendy; Bradly G. Wouters | Zendy; Benjamin A. Garcia | Zendy; C.H. Arrowsmith | Zendy; Poul H. Sorensen | Zendy; Stéphane Angers | Zendy; Nada Jabado | Zendy; Peter B. Dirks | Zendy; Stephen C. Mack | Zendy; Sameer Agnihotri | Zendy; Jeremy N. Rich | Zendy; Michael D. Taylor | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

Author(s) -

Kulandaimanuvel Antony Michealraj,

Sachin Kumar,

Leo J.Y. Kim,

Florence M.G. Cavalli,

David Przelicki,

John Wojcik,

Alberto Delaidelli,

Andrea Bajic,

Olivier Saulnier,

Graham MacLeod,

Ravi N. Vellanki,

Maria C. Vladoiu,

Paul Guilhamon,

Winnie Ong,

John J. Y. Lee,

Yanqing Jiang,

Borja Holgado,

Alex Rasnitsyn,

Ahmad Malik,

Ricky Tsai,

Cory Richman,

Kyle Juraschka,

Joonas Haapasalo,

Evan Y. Wang,

Pasqualino de Antonellis,

Hiromichi Suzuki,

Hamza Farooq,

Polina Balin,

Kaitlin Kharas,

Randy Van Ommeren,

Olga Sirbu,

Avesta Rastan,

Stacey Krumholtz,

Michelle Ly,

Moloud Ahmadi,

Geneviève Deblois,

Dilakshan Srikanthan,

Betty Luu,

James Loukides,

Xiaochong Wu,

Livia Garzia,

Vijay Ramaswamy,

Evgeny Kanshin,

María SánchezOsuna,

Ibrahim El-Hamamy,

Fiona J. Coutinho,

Panagiotis Prinos,

Sheila K. Singh,

Laura Donovan,

Craig Daniels,

Daniel Schramek,

Mike Tyers,

Samuel Weiss,

Lincoln Stein,

Mathieu Lupien,

Bradly G. Wouters,

Benjamin A. Garcia,

C.H. Arrowsmith,

Poul H. Sorensen,

Stéphane Angers,

Nada Jabado,

Peter B. Dirks,

Stephen C. Mack,

Sameer Agnihotri,

Jeremy N. Rich,

Michael D. Taylor

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.04.047

Subject(s) - biology , epigenome , ependymoma , medulloblastoma , epigenetics , histone , cancer research , acetylation , histone h3 , microbiology and biotechnology , dna methylation , genetics , pathology , medicine , gene expression , gene

Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for which model systems are lacking. Here we demonstrate that PFA ependymomas are maintained under hypoxia, associated with restricted availability of specific metabolites to diminish histone methylation, and increase histone demethylation and acetylation at histone 3 lysine 27 (H3K27). PFA ependymomas initiate from a cell lineage in the first trimester of human development that resides in restricted oxygen. Unlike other ependymomas, transient exposure of PFA cells to ambient oxygen induces irreversible cellular toxicity. PFA tumors exhibit a low basal level of H3K27me3, and, paradoxically, inhibition of H3K27 methylation specifically disrupts PFA tumor growth. Targeting metabolism and/or the epigenome presents a unique opportunity for rational therapy for infants with PFA ependymoma.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research