Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection | Zendy

Mihai G. Netea | Zendy; Evangelos J. GiamarellosBourboulis | Zendy; Jorge DomínguezAndrés | Zendy; Nigel Curtis | Zendy; Reinout van Crevel | Zendy; Frank L. van de Veerdonk | Zendy; Marc J. M. Bonten | Zendy

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Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

Author(s) -

Mihai G. Netea,

Evangelos J. GiamarellosBourboulis,

Jorge DomínguezAndrés,

Nigel Curtis,

Reinout van Crevel,

Frank L. van de Veerdonk,

Marc J. M. Bonten

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.04.042

Subject(s) - biology , immunity , virology , immunology , covid-19 , immune system , disease , infectious disease (medical specialty) , medicine , outbreak

SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the elderly and individuals with co-morbidities argues for an initial defect in anti-viral host defense mechanisms. Long-term boosting of innate immune responses, also termed "trained immunity," by certain live vaccines (BCG, oral polio vaccine, measles) induces heterologous protection against infections through epigenetic, transcriptional, and functional reprogramming of innate immune cells. We propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.

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