Feeling Stressed? Piezo1-Mediated Loss of Heterochromatin Buys Time for Long-Term Adaptation | Zendy

Jan Lammerding | Zendy; Chieh-Ren Hsia | Zendy

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Feeling Stressed? Piezo1-Mediated Loss of Heterochromatin Buys Time for Long-Term Adaptation

Author(s) -

Jan Lammerding,

Chieh-Ren Hsia

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.04.041

Subject(s) - heterochromatin , biology , cytoskeleton , lamin , microbiology and biotechnology , dna damage , nucleus , dna repair , nuclear lamina , cytoplasm , cell , biophysics , chromatin , dna , genetics , nuclear protein , gene , transcription factor

Skin and other epithelial cell layers are frequently subjected to extensive deformations, yet sustain such mechanical stress without damage. In this issue of Cell, Nava and colleagues show that stretch induces rapid loss of heterochromatin that leads to transient softening of the nucleus, which, together with long-term cytoskeletal and supracellular rearrangements, protects nuclei from DNA damage.

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