Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy | Zendy

Jukka Westermarck | Zendy; Benjamin G. Neel | Zendy

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Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy

Author(s) -

Jukka Westermarck,

Benjamin G. Neel

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.04.005

Subject(s) - biology , protein phosphatase 2 , suppressor , cancer , serine , phosphatase , isozyme , cancer research , tumor suppressor gene , threonine , genetics , phosphorylation , carcinogenesis , biochemistry , enzyme

Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlike most tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins." Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases.

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