Open AccessSLeuthing Tuberculous Cough
Author(s) -
Marcel A. Behr,
Paul H. Edelstein,
Lalita Ramakrishnan
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.03.057
Subject(s) - cough reflex , chronic cough , nociceptor , reflex , medicine , nociception , anesthesia , immunology , asthma , receptor
Cough, a hallmark of tuberculosis, transmits the disease. Ruhl et al. find that a Mycobacterium tuberculosis (Mtb)-specific lipid, SL-1, stimulates human nociceptive neurons and makes guinea pigs cough. Mtb extract, but not SL-1, also stimulates non-nociceptive neurons that participate in the cough reflex, suggesting additional cough-inducing mechanisms.
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