Networking and Dynamic Switches in Biological Condensates | Zendy

Ashok A. Deniz | Zendy

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Networking and Dynamic Switches in Biological Condensates

Author(s) -

Ashok A. Deniz

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.03.056

Subject(s) - biology , stress granule , rna , context (archaeology) , function (biology) , microbiology and biotechnology , computational biology , biophysics , genetics , messenger rna , translation (biology) , gene , paleontology

Cellular liquid-liquid phase separation (LLPS) plays a key role in the dynamics and function of RNA-protein condensates like stress granules. In this issue of Cell, Yang et al., Guillén-Boixet et al., and Sanders et al. use a combination of experiment and modeling to provide an exciting mechanistic insight into the relationship between stress granules and LLPS, for example, in the context of protein disorder, switchable interactions, graph theory, and multiple interacting dense phases.

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