SnapShot: Cancer-Associated Fibroblasts
Author(s) -
Danielle Park,
Erik Sahai,
Antonio Rullan
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.03.013
Subject(s) - biology , snapshot (computer storage) , cancer associated fibroblasts , tumor microenvironment , population , cancer research , microbiology and biotechnology , tumor cells , computer science , demography , sociology , operating system
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment and have both tumor-promoting and tumor-suppressive functions. This SnapShot summarizes the origins of CAFs, their diverse functions, and how this relates to heterogeneity within the population. The suitability of targeting CAFs therapeutically is also discussed.
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