Open AccessRepair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation
Author(s) -
Kook Son,
Orlando D. Schärer
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.02.053
Subject(s) - cockayne syndrome , rna polymerase ii , biology , nucleotide excision repair , transcription (linguistics) , dna damage , dna repair , microbiology and biotechnology , polymerase , dna , gene , genetics , gene expression , promoter , linguistics , philosophy
Two papers, by Nakazawa and Vidaković, show how ubiquitylation of a single lysine residue in RNA polymerase II serves as a master switch to regulate transcription, RNA polymerase II degradation, and transcription-coupled nucleotide excision repair in response to DNA damage.
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