Open AccessBoosting Cytotoxic Antibodies against Cancer
Author(s) -
Laurent Gauthier,
Éric Vivier
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.02.025
Subject(s) - biology , monoclonal antibody , antigen , cytotoxic t cell , antibody , cancer cell , cancer research , boosting (machine learning) , immunology , cancer , genetics , in vitro , machine learning , computer science
Monoclonal antibodies (mAbs) targeting antigens expressed at the surface of tumor cells are widely used for cancer control in clinics, but these treatments need to be improved. Chew et al. show how an old drug, prochlorperazine, could be repurposed to enhance the efficacy of anti-tumor mAbs by increasing the cell-surface expression of tumor antigens.
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