Open AccessThe Nucleotide-Free State of the Cannabinoid CB2/Gi Complex
Author(s) -
Diane L. Lynch,
Dow P. Hurst,
Patricia H. Reggio
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.01.034
Subject(s) - biology , cannabinoid , cannabinoid receptor , cannabinoid receptor type 2 , agonist , receptor , ligand (biochemistry) , microbiology and biotechnology , nucleotide , computational biology , biochemistry , gene
In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling.
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