Open AccessAn IRON-clad Connection between Aging Organelles
Author(s) -
Hongying Shen
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.12.037
Subject(s) - biology , vacuole , compartmentalization (fire protection) , organelle , mitochondrion , microbiology and biotechnology , lysosome , autophagy , mitophagy , mechanism (biology) , cytoplasm , biochemistry , apoptosis , enzyme , philosophy , epistemology
Lysosome (vacuole) and mitochondria decline interdependently during aging through an unclear mechanism. In this issue of Cell, Hughes et al. (2020) show that defective vacuole-mediated cysteine compartmentalization in aging yeast leads to iron limitation and mitochondrial dysfunction.
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