It’s Hard to Teach an Old B Cell New Tricks | Zendy

Jenna J. Guthmiller | Zendy; Patrick C. Wilson | Zendy

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It’s Hard to Teach an Old B Cell New Tricks

Author(s) -

Jenna J. Guthmiller,

Patrick C. Wilson

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.12.019

Subject(s) - germinal center , somatic hypermutation , biology , affinity maturation , memory b cell , b cell , antibody , antigen , naive b cell , b 1 cell , immunology , microbiology and biotechnology , immune system , t cell , antigen presenting cell

Victora and colleagues challenge current perceptions that memory B cells readily participate in secondary germinal center reactions, allowing further modification of specificity upon reactivation. Rather, naïve B cells are the predominant B cell type that populate secondary germinal centers. This work has important basic immunological and translational implications.

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