SnapShot: Splicing Alterations in Cancer | Zendy

Mohammad Alinoor Rahman | Zendy; Adrian R. Krainer | Zendy; Omar AbdelWahab | Zendy

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SnapShot: Splicing Alterations in Cancer

Author(s) -

Mohammad Alinoor Rahman,

Adrian R. Krainer,

Omar AbdelWahab

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.12.011

Subject(s) - rna splicing , biology , spliceosome , splicing factor , snapshot (computer storage) , alternative splicing , genetics , polypyrimidine tract , rna binding protein , exonic splicing enhancer , intron , gene , messenger rna , computational biology , rna , microbiology and biotechnology , computer science , operating system

RNA splicing, the spliceosome-catalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a number of ways in cancer. Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors. This SnapShot summarizes our current understanding of splicing-factor alterations in cancers. To view this SnapShot, open or download the PDF.

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