Open AccessStabilizing HIF to Ameliorate Anemia
Author(s) -
Richard A. Voit,
Vijay G. Sankaran
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.12.010
Subject(s) - erythropoietin , biology , anemia , kidney disease , transcription factor , kidney , hypoxia inducible factors , endocrinology , medicine , cancer research , biochemistry , gene
Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chronic kidney disease (CKD).
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