The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine | Zendy

Dane J. Dickson | Zendy; Jennifer E. Johnson | Zendy; Raymond C. Bergan | Zendy; Rebecca Owens | Zendy; Vivek Subbiah | Zendy; Razelle Kurzrock | Zendy

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The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine

Author(s) -

Dane J. Dickson,

Jennifer E. Johnson,

Raymond C. Bergan,

Rebecca Owens,

Vivek Subbiah,

Razelle Kurzrock

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.12.009

Subject(s) - observational study , protocol (science) , medical physics , clinical trial , class (philosophy) , construct (python library) , biology , randomized controlled trial , computer science , bioinformatics , alternative medicine , artificial intelligence , medicine , pathology , programming language

This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data. The MOT provides a clinical venue to allow molecular medicine to rapidly advance, answers questions that traditional interventional trials generally do not address, and seamlessly integrates with interventional trials in both diagnostic and therapeutic arenas. The result is a more comprehensive data collection ecosystem in precision medicine.

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