Open AccessModeling the Evolution of Human Brain Development Using Organoids
Author(s) -
Sydney Muchnik,
Belén Lorente-Galdós,
Gabriel Santpere,
Nenad Šestan
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.10.041
Subject(s) - biology , organoid , macaque , human brain , transcriptome , evolutionary biology , computational biology , neuroscience , gene , genetics , gene expression
In a recent issue of Nature, Kanton et al. explore human brain evolution and development by profiling the single-cell transcriptomes and epigenomes of cerebral organoids derived from human, chimpanzee, and macaque stem cells. Their results reveal key molecular characteristics that differentiate humans and non-human primates at the earliest stages of brain development.
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