Open AccessClose to the Bone: Tissue-Specific Checkpoint Immunotherapy Evasion
Author(s) -
Vincenzo Bronte
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.10.022
Subject(s) - biology , evasion (ethics) , immunotherapy , immunology , cancer research , immune system
Primary or secondary resistance to immune checkpoint therapy is often analyzed in primary tumors rather than metastases. In this issue of Cell, Jiao et al. show that the site of metastatic diffusion matters and bones empower a particularly hostile environment.
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