Open AccessThe Texture of Chromatin
Author(s) -
Fedor Kouzine,
David Levens
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.09.026
Subject(s) - biology , chromatin , texture (cosmology) , microbiology and biotechnology , computational biology , genetics , evolutionary biology , dna , artificial intelligence , computer science , image (mathematics)
DNA-replication machinery introduces intertwining and supercoiling of DNA strands as it traverses the double helix, which could impede replication and compromise genome stability. A new study in Cell shows that the intrinsic physical properties of chromatin fibers dictate how torsional stress is partitioned to minimize these risks and facilitate DNA replication.
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