PiRNAs Rise to Rescue Koalas | Zendy

Astrid D. Haase | Zendy; Todd S. Macfarlan | Zendy

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PiRNAs Rise to Rescue Koalas

Author(s) -

Astrid D. Haase,

Todd S. Macfarlan

Publication year - 2019

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.09.025

Subject(s) - biology , piwi interacting rna , germline , genome , rasirna , innate immune system , rna , genetics , small rna , acquired immune system , argonaute , computational biology , evolutionary biology , rna interference , gene , transposable element , immune system

PIWI-interacting small RNAs (piRNAs) establish sequence-specific adaptive restriction of resident genomic parasites to guard genome integrity. In this issue of Cell, Yu, Koppetsch, et al. describe an innate piRNA-response that specifically fragments the viral RNA genome in the germline of recently invaded koalas. This first line of defense might ensure survival until adaptive immunity develops.

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