Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma | Zendy

Qiang Gao | Zendy; Hongwen Zhu | Zendy; Liangqing Dong | Zendy; Weiwei Shi | Zendy; Ran Chen | Zendy; Zhijian Song | Zendy; Chen Huang | Zendy; Junqiang Li | Zendy; Xiaowei Dong | Zendy; Yanting Zhou | Zendy; Qian Liu | Zendy; Lijie Ma | Zendy; Xiaoying Wang | Zendy; Jian Zhou | Zendy; Yansheng Liu | Zendy; Emily S. Boja | Zendy; Ana I. Robles | Zendy; Weiping Ma | Zendy; Pei Wang | Zendy; Yize Li | Zendy; Li Ding | Zendy; Bo Wen | Zendy; Bing Zhang | Zendy; Henry Rodriguez | Zendy; Daming Gao | Zendy; Hu Zhou | Zendy; Jia Fan | Zendy

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Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

Author(s) -

Qiang Gao,

Hongwen Zhu,

Liangqing Dong,

Weiwei Shi,

Ran Chen,

Zhijian Song,

Chen Huang,

Junqiang Li,

Xiaowei Dong,

Yanting Zhou,

Qian Liu,

Lijie Ma,

Xiaoying Wang,

Jian Zhou,

Yansheng Liu,

Emily S. Boja,

Ana I. Robles,

Weiping Ma,

Pei Wang,

Yize Li,

Li Ding,

Bo Wen,

Bing Zhang,

Henry Rodriguez,

Daming Gao,

Hu Zhou,

Jia Fan

Publication year - 2019

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.08.052

Subject(s) - hepatocellular carcinoma , biology , proteogenomics , cancer research , proteome , proteomics , liver cancer , hepatitis b virus , reprogramming , computational biology , bioinformatics , cell , transcriptome , immunology , virus , genetics , gene , gene expression

We performed the first proteogenomic characterization of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 patients. Integrated proteogenomic analyses revealed consistency and discordance among multi-omics, activation status of key signaling pathways, and liver-specific metabolic reprogramming in HBV-related HCC. Proteomic profiling identified three subgroups associated with clinical and molecular attributes including patient survival, tumor thrombus, genetic profile, and the liver-specific proteome. These proteomic subgroups have distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics. Two prognostic biomarkers, PYCR2 and ADH1A, related to proteomic subgrouping and involved in HCC metabolic reprogramming, were identified. CTNNB1 and TP53 mutation-associated signaling and metabolic profiles were revealed, among which mutated CTNNB1-associated ALDOA phosphorylation was validated to promote glycolysis and cell proliferation. Our study provides a valuable resource that significantly expands the knowledge of HBV-related HCC and may eventually benefit clinical practice.

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