Counting the Cuts: MAZTER-Seq Quantifies m6A Levels Using a Methylation-Sensitive Ribonuclease | Zendy

Radha Raman Pandey | Zendy; Ramesh S. Pillai | Zendy

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Counting the Cuts: MAZTER-Seq Quantifies m6A Levels Using a Methylation-Sensitive Ribonuclease

Author(s) -

Radha Raman Pandey,

Ramesh S. Pillai

Publication year - 2019

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.07.006

Subject(s) - biology , methylation , ribonuclease , genetics , dna methylation , computational biology , microbiology and biotechnology , rna , gene , gene expression

Garcia-Campos et al. describe MAZTER-seq, which deploys a sequence-specific, methylation-sensitive bacterial single-stranded ribonuclease MazF to provide nucleotide-resolution quantification of m 6 A methylation sites. The study reveals many new sites and supports the idea of a predictable "m 6 A code," where methylation levels are dictated primarily by local sequence at the site of methylation.

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