Open AccessSenescence Evasion in Chemotherapy: A Sweet Spot for p21
Author(s) -
Humza M. Ashraf,
Justin Moser,
Sabrina L. Spencer
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.06.025
Subject(s) - biology , senescence , sweet spot , evasion (ethics) , microbiology and biotechnology , genetics , immune system , paleontology , shear (geology)
Time-lapse imaging reveals a nuanced role for p21 in cancer cells challenged with chemotherapeutic drugs: cells with either high or low p21 are biased toward senescence, whereas intermediate p21 allows cells to re-enter the cell cycle after drug treatment.
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