Open Access“Breathing” Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design
Author(s) -
Yan Wu,
George F. Gao
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.04.034
Subject(s) - biology , hemagglutinin (influenza) , epitope , virology , influenza vaccine , glycoprotein , epitope mapping , immunology , vaccination , genetics , antibody , virus
A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe article, three studies identify broad protective epitopes in the hemagglutinin head domain that are exposed by trimer "breathing."
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