The Least Mating Pathway: Synthetically Refactoring a Familiar Signaling System for New Applications | Zendy

Ronan W. O’Connell | Zendy; Caleb J. Bashor | Zendy

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The Least Mating Pathway: Synthetically Refactoring a Familiar Signaling System for New Applications

Author(s) -

Ronan W. O’Connell,

Caleb J. Bashor

Publication year - 2019

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.04.003

Subject(s) - code refactoring , biology , computational biology , synthetic biology , modularity (biology) , systems biology , gene regulatory network , context (archaeology) , gene , genetics , computer science , software , programming language , paleontology , gene expression

Synthetic refactoring makes naturally occurring regulatory systems more amenable to manipulation by removing or recoding their natural genetic complexity. Shaw et al. apply this technique to the yeast mating response pathway, creating a simplified, highly engineerable signaling module that can be used to construct precisely optimized, application-specific GPCR biosensors.

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