Polygenic Risk Scores Expand to Obesity | Zendy

Ali Torkamani | Zendy; Eric J. Topol | Zendy

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Polygenic Risk Scores Expand to Obesity

Author(s) -

Ali Torkamani,

Eric J. Topol

Publication year - 2019

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.03.051

Subject(s) - obesity , polygenic risk score , biology , childhood obesity , multifactorial inheritance , environmental health , bioinformatics , genetics , endocrinology , overweight , gene , single nucleotide polymorphism , medicine , genotype

Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity. This genetic risk expresses itself early as childhood obesity, reinforcing the notion that early prevention is essential to combatting the obesity epidemic.

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