Open Access“Cloaking” on Time: A Cover-Up Act by Resident Tissue Macrophages
Author(s) -
Camille Blériot,
Lai Guan Ng,
Florent Ginhoux
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.03.042
Subject(s) - biology , macrophage , microbiology and biotechnology , intravital microscopy , cover (algebra) , cloaking , cell , cloak , genetics , optics , mechanical engineering , physics , metamaterial , in vivo , engineering , in vitro
In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell "macrolesions" are characteristically pro-inflammatory, resident macrophages can "cloak" single-cell microlesions to prevent excessive neutrophil recruitment and limit subsequent tissue damage.
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