Open AccessDoes Autophagy Promote Longevity? It Depends.
Author(s) -
Marzia Savini,
Meng C. Wang
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.03.021
Subject(s) - autophagy , longevity , biology , caenorhabditis elegans , microbiology and biotechnology , mitochondrion , genetics , apoptosis , gene
Zhou et al. challenge the well-known beneficial effect of autophagy in promoting longevity. Evidence presented demonstrate that autophagy induction coupled with increased mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis elegans and mammals.
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