Genetics of Common, Complex Coronary Artery Disease | Zendy

Kiran Musunuru | Zendy; Sekar Kathiresan | Zendy

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Genetics of Common, Complex Coronary Artery Disease

Author(s) -

Kiran Musunuru,

Sekar Kathiresan

Publication year - 2019

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2019.02.015

Subject(s) - biology , coronary artery disease , disease , ethnic group , genetics , medicine , sociology , anthropology

Coronary artery disease represents the leading cause of death worldwide, sparing no nation, ethnicity, or economic stratum. Coronary artery disease is partly heritable. While enormous effort has been devoted to understanding the genetic basis of coronary artery disease and other common, complex cardiovascular diseases, key challenges have emerged in gene discovery, in understanding how DNA variants connect to function, and in translation of genetics to the clinic. We discuss these challenges as well as promising opportunities to bring the work closer to fruition.

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