GABAAR Modulator for Postpartum Depression | Zendy

István Módy | Zendy

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GABAAR Modulator for Postpartum Depression

Author(s) -

István Módy

Publication year - 2019

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.12.016

Subject(s) - neuroactive steroid , postpartum depression , biology , postpartum period , pregnancy , gabaa receptor , mood , depression (economics) , period (music) , allopregnanolone , receptor , neuroscience , psychiatry , medicine , genetics , physics , macroeconomics , acoustics , economics

During the postpartum period, the brain's inhibitory GABAA receptors may not recover in time following their reduced numbers during pregnancy. This is likely the cause of postpartum depression prevalent in ∼12% of childbearing women. A new therapy for this condition consists of administering a synthetic neurosteroid during the postpartum period to alleviate the mood disorder. To view this Bench to Bedside, open or download the PDF.

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