Open AccessN4-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and Translation
Author(s) -
Dan Dominissini,
Gideon Rechavi
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.11.037
Subject(s) - biology , cytidine , acetylation , translation (biology) , messenger rna , microbiology and biotechnology , genetics , biochemistry , gene , enzyme
Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N 4 -acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.
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