Open AccessMechanobiology of Protein Droplets: Force Arises from Disorder
Author(s) -
Timothy J. Welsh,
Yi Shen,
Aviad Levin,
Tuomas P. J. Knowles
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.11.020
Subject(s) - mechanobiology , biology , microbiology and biotechnology , biophysics
The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.
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